A new article in Aging Cell describes reduced chromosome cohesion with advanced maternal age. The authors Duncan, Hornick, Lampson, Schultz, Shea, and Woodruff identify that eggs from older women which were obtained following in vitro maturation resulted in an increased inter-kinetochore distance between sister chromatids. This distance, which indicates reduced chromosome cohesion, may contribute to the increased rates of aneuploidy seen with increased maternal age.