Building off our work in the mouse and nonhuman primate models, we recently showed that we can grow human secondary follicles in the alginate hydrogel-based follicle culture system. Early secondary follicles, isolated from ovarian tissues from human cancer patients, grew to the antral stage after thirty days in culture. These follicles produced hormones, had intact somatic cell-oocyte architecture, and contained oocytes that appeared to have nuclear competence. This breakthrough highlights the huge potential of translating bench science into clinical practice for fertility preservation.
|In Vitro Grown Human Ovarian Follicles From Cancer Patients Support Oocyte Growth||Research Resources, Basic Science, Human Follicle Culture, Oncofertility-Related Publications||Download|
|Noninvasive Index of Cyrorecovery and Growth Potential for Human Follicles In Vitro||Research Resources, Basic Science, Human Follicle Culture, Oncofertility-Related Publications||Download|