The Oncofertility Consortium has made instrumental basic science breakthroughs in follicle biology, and ongoing efforts are underway to translate these successes into clinical practice.  We developed a novel alginate hydrogel-based in vitro follicle culture system that maintains the follicle's three-dimensional architecture as it grows.  This culture system, which was first optimized in a mouse model system, results in fertilization-competent female gametes that are capable of giving rise to live offspring.  We have extended this in vitro culture system to other species and have successfully cultured nonhuman primate and human follicles.  A major goal of the Division of Fertility Preservation of Northwestern is to disseminate key resources to researchers worldwide so that we can continually broaden our research horizons.  Here you will find Oncofertility-related basic science and clinical medicine research resources including our key methods, protocols, publications, presentations, and videos.

 

Oncofertility Consortium Research and Pilot Projects
The Oncofertility Consortium has developed a comprehensive research program for addressing the needs of young cancer patients who want to preserve their fertility. To meet its goals, the Consortium has undertaken a number of diverse projects and established core resources that reach across several diverse disciplines.

Learn more about the Oncofertility Consortium Projects

 

Oncofertility Methods
Here basic science researchers will find protocols and videos detailing follicle isolation from the ovary, encapsulation in alginate, and growth in vitro.  Additional protocols include encapsulation in a fibrin/alginate blend, removal of follicles from alginate, in vitro maturation of oocytes from antral follicles derived from in vitro follicle growth, and whole follicle immunocytochemistry.   Researchers will also find resources for establishing in vitro follicle growth systems in their labs including a supplies checklist, a follicle reference guide, and requirements for follicle work certification.  Requests for a hands-on training session at the Division of Fertility Preservation can also be made here.  Clinicians will find videos that delineate fertility preservations options for patients and that show how to manipulate the human ovary for fertility preservation procedures.  

Learn more about Oncofertility Methods

 

 

Selected Oncofertility Publications
Since its inception less than a decade ago, the field of Oncofertility and its associated research has burgeoned. As a testament to Oncofertility’s far reach and broad scope, we have published numerous peer-reviewed journal articles, reviews, book chapters, as well as two books on the subject.  These publications span several disciplines including basic science, clinical medicine, social science, and the humanities.  Here you will find our most recent relevant publications organized by topic.

View selected Oncofertility publications

 
 

Media Archive
Look here to find training videos of Oncofertility methods as well as video recordings of key events including the 2007-2009 annual Oncofertility Consortium Conferences, the Oncofertility Consortium’s Virtual Grand Rounds, and Webinars.

View media for researchers