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Dr. Francesca Duncan and her colleagues recently published in the Proceedings of the National Academy of Sciences (PNAS).
This paper "mTORC1/2 Inhibition Preserves Ovarian Function and Fertility during Genotoxic Chemotherapy" is significant for the following reasons: "A major unresolved issue for premenopausal women undergoing chemotherapy is infertility due to the loss of nonrenewable ovarian primordial follicles. We show that pharmacologic down-regulation of the mammalian/mechanistic target of rapamycin (mTOR) pathway during chemotherapy in a mouse model prevents activation of primordial follicles, preserves ovarian function, and maintains normal fertility using clinically available inhibitors of mTOR complex (C)1 and mTORC1/2. These findings represent a feasible pharmacologic approach for preservation of ovarian function and fertility during treatment with conventional chemotherapy."
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