J. Smitz,11,†, M.M. Dolmans, J. Donnez, J.E. Fortune, O. Hovatta, K. Jewgenow, H.M. Picton, C. Plancha, L.D. Shea, R.L. Stouffer, E.E. Telfer, T.K. Woodruff, and M.B. Zelinski. Human Reproduction Update, Vol.16, No.4 pp. 395–414, 2010.
Abstract BACKGROUND: Female cancer patients are offered ‘banking’ of gametes before starting fertility-threatening cancer therapy. Transplants of fresh and frozen ovarian tissue between healthy fertile and infertile women have demonstrated the utility of the tissue banked for restoration of endocrine and fertility function. Additional methods,…
We often discuss the many ways young people can preserve their fertility prior to undergoing medical procedures that may leave them sterile. One of these fertility preservation options, ovarian tissue cryopreservation, or freezing, has recently been reported in the Lancet medical journal, to also successfully…
Pediatric and Adolescent Committee and Basic Science Committee Ovarian Tissue Resources The advent of ovarian tissue cryopreservation has allowed an unprecedented view of young pediatric ovaries. Now that this procedure is no longer considered experimental it is performed at many sites throughout the United States.…
Who are appropriate candidates? Ovarian tissue cryopreservation is usually only considered in certain cases: Patients who do not have time to undergo controlled ovarian stimulation (COS) for embryo or oocyte cryopreservation. COS is the more mature technology and should be the first-line treatment if time allows. Patients…
Abstract BACKGROUND: Young female adult and adolescent cancer patients facing life-preserving but fertility-threatening chemo- or radiation-therapy are increasingly seeking options to protect their reproductive potential. Ovarian tissue cryopreservation with transplantation is a promising technique to safeguard fertility in cancer patients. However, this method may risk…
Abstract Ovarian tissue transplantation is an experimental procedure that can be used to treat both infertility and premature menopause. Working within the current legal framework in the USA, I examine whether ovarian tissue should be legally treated like gametes or organs in the case of…
Abstract Ovarian cryopreservation before chemotherapy and autotransplantation post-treatment can restore fertility to women with premature ovarian failure. Although the majority of primordial follicles survive the cryopreservation cycle, the follicular pool is reduced after transplantation due to ischemic death. Therefore, we engineered a biomaterial-based system to…
Today we continue our series highlighting reproductive medicine blog posts written by Lisa Campo-Engelstein, PhD, from the Alden March Bioethics Institute at Albany Medical College for BIOETHICS TODAY. Dr. Campo-Engelstein's main research areas include reproductive ethics (particularly contraception, oncofertility, birth, and embry and parthenote research), gender and medicine, cancer…
Today we continue a new series highlighting reproductive medicine blog posts written by Lisa Campo-Engelstein, PhD, from the Alden March Bioethics Institute at Albany Medical College for BIOETHICS TODAY. Dr. Campo-Engelstein's main research areas include reproductive ethics (particularly contraception, oncofertility, birth, and embry and parthenote research), gender and medicine,…
Jacques Donnez and Marie-Madeline Dolmans published their article, Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice, in the Journal of Assisted Reproduction and Genetics. The article describes the success and expansion of ovarian tissue cryopreservation…
Dr. Mary Zelinski of Oregon Health Sciences University spoke about advances in vitrification of ovarian tissue and follicles in primates. She reviewed her lab’s technique for vitrification in a closed system which has been shown to preserve primordial, primary and secondary follicles in Macaques. Since,…
Two ovarian follicles at different stages of maturation (primary on the left, secondary on the right). Women with ovarian lesions, such as benign or malignant tumors, or those at high risk for breast or ovarian cancer now have additional evidence that can help them decide…
The reproductive community took note recently with the publication of research stating that ovarian tissue cryopreserved using a technique called vitrification, has resulted in a live human birth. Ovarian tissue cryopreservation is an experimental fertility preservation technique that involves the surgical removal of an ovary,…
In a publication in Tissue Engineering, Oncofertility Consortium researchers identified new methods that may be utilized to increase the success of ovarian transplantation after cryopreservation. When ovarian tissue is transplanted back into a woman who preserved her fertility, revascularization of the tissue takes some time,…
Mary Zelinski, PhD finishes her reports from the annual meeting of the Society for Cryobiology held from Corvallis, Oregon with a final blog about the keynote talk from Alison Ting, PhD. In this post, she relay’s Dr. Ting’s findings about advancing ovarian tissue cryopreservation techniques…
As recently reported in BBC News and Human Reproduction, a mother in Denmark has become the first in the world to give birth to a second child after an ovary transplant operation. Stinne Holm Bergholodt was diagnosed with Ewing’s sarcoma at age 27 in March…
Several research groups in our Oncofertility Consortium Network have Recruiting Clinical Trials listed on ClinicalTrials.gov as shown below: Autologous Ovarian Tissue Transplantation Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting Testicular Tissue Cryopreservation for Fertility Preservation Gonadal Tissue Freezing for Fertility Preservation in Individuals…
Undertook the research foundation of the National Fund Project “TGF-β/Smads Signal Pathway in Stem Cell Transplantation for Chemotherapy Impaired Premature Ovarian Failure (POF)” (81360095)”, and actively declare “Medral Mesenchymal Stem Cell Therapy for POF with Infertility” The study was applied to the clinic after being…
Cryopreservation of ovarian tissue: experience of the Policlinico S.Orsola-Malpighi of Bologna The Gynecology and Physiopathology Unit of Human Reproduction of the S. Orsola-Malpighi Polyclinic, equipped with a Cryobank dedicated to the cryopreservation of ovarian tissue, is the structure with the widest nationwide case history. Since…
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